Correlations between integrin {alphanubeta6} expression and clinico-pathological features in stage B and stage C rectal cancer

Seong Beom Ahn, Abidali Mohamedali, Charles Chan, Julie Fletcher, Sun Young Kwun, Candice Clarke, Owen F Dent, Pierre H Chapuis, Edouard C Nice, Mark S Baker

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9 Citations (Scopus)

Abstract

Integrin alphanubeta6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between alphanubeta6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of alphanubeta6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of alphanubeta6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p
Original languageEnglish
Pages (from-to)1 - 8
Number of pages8
JournalPLoS ONE
Volume9
Issue number5 (Art. ID: e97248)
DOIs
Publication statusPublished - 2014

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