Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation

David Bark Jr.; Andrea N Para; David Ku

doi:10.1002/bit.24537

Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation

David Bark Jr., Andrea N Para, David Ku

Australian Centre for Blood Diseases

Research output: Contribution to journal › Article › Research › peer-review

96 Citations (Scopus)

Abstract

Local hemodynamics may strongly influence atherothrombosis, which can lead to acute myocardial infarction and stroke. The relationship between hemodynamics and thrombosis during platelet accumulation was studied through an in vitro flow system consisting of a stenosis. Specifically, wall shear rates (WSR) ranging from 0 to 100,000s-1 were ascertained through computations and compared with thrombus growth rates found by image analysis for over 5,000 individual observation points per experiment. A positive correlation (P6,000s-1 (P

Original language	English
Pages (from-to)	2642 - 2650
Number of pages	9
Journal	Biotechnology and Bioengineering
Volume	109
Issue number	10
DOIs	https://doi.org/10.1002/bit.24537
Publication status	Published - 2012

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Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation

Abstract

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