Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation

David Bark Jr., Andrea N Para, David Ku

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Abstract

Local hemodynamics may strongly influence atherothrombosis, which can lead to acute myocardial infarction and stroke. The relationship between hemodynamics and thrombosis during platelet accumulation was studied through an in vitro flow system consisting of a stenosis. Specifically, wall shear rates (WSR) ranging from 0 to 100,000s-1 were ascertained through computations and compared with thrombus growth rates found by image analysis for over 5,000 individual observation points per experiment. A positive correlation (P6,000s-1 (P
Original languageEnglish
Pages (from-to)2642 - 2650
Number of pages9
JournalBiotechnology and Bioengineering
Volume109
Issue number10
DOIs
Publication statusPublished - 2012

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