Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst

Derek Denton, Robert Shade, Frank Zamarippa, Gary Egan, John Blair-West, Michael Mckinley, Peter Fox

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Positron emission tomography studies were conducted during genesis of moderate thirst by rapid i.v. infusion of hypertonic saline (0.51 M) and after satiation of thirst by drinking water. The correlation of regional cerebral blood flow with the change in the plasma Na concentration showed a significant group of cerebral activations in the anterior cingulate region and also a site in the middle temporal gyrus and in the periaqueductal gray. Strongest deactivations occurred in the parahippocampal and frontal gyri. The data are consistent with an important role of the anterior cingulate in the genesis of thirst.

Original languageEnglish
Pages (from-to)2532-2537
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number5
Publication statusPublished - 2 Mar 1999
Externally publishedYes

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