Corpus callosum size and shape alterations in individuals with bipolar disorder and their first-degree relatives

Mark Walterfang, Amanda Gabrielle Wood, Sarah Barton, Dennis Velakoulis, Jian Chen, David Charles Reutens, Matthew Kempton, Morgan Haldane, Christos Pantelis, Sophia Frangou

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52 Citations (Scopus)

Abstract

Corpus callosum size and shape alterations in individuals with bipolar disorder and their first-degree relatives. Reductions in the size of the corpus callosum (CC) have been described in patients with bipolar disorder (BD), although the contribution of genetic factors to these changes is unclear. We previously showed a global thinning of the CC in BD patients, and found those with a family history of affective disorders had a larger CC than those without. In this study, we compared callosal size and shape in 180 individuals: 70 with BD, 45 of their first-degree relatives, and 75 healthy controls. The callosum was extracted from a mid-sagittal slice from T1-weighted magnetic resonance images, and its total area, length and curvature were compared across groups.
Original languageEnglish
Pages (from-to)1050 - 1057
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number6
Publication statusPublished - 2009

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