Corpus callosal atrophy in premanifest and early Huntington's disease

Helen Crawford, Nicola Z Hobbs, Ruth Keogh, Douglas R Langbehn, Chris Frost, Hans J Johnson, Bernhard G Landwehrmeyer, Ralph Reilmann, David O Craufurd, Julie C Stout, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Sarah J Tabrizi, Rachael I Scahill

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25 Citations (Scopus)


Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington s Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas. To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks. Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A =10.8 and 47 preHD-B
Original languageEnglish
Pages (from-to)517 - 526
Number of pages10
JournalJournal of Huntington's Disease
Issue number4
Publication statusPublished - 2013

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