TY - JOUR
T1 - Coronavirus disease 2019 among pregnant Chinese women
T2 - Case series data on the safety of vaginal birth and breastfeeding
AU - Wu, Yanting
AU - Liu, Chen
AU - Dong, Lan
AU - Zhang, Chenjie
AU - Chen, Yang
AU - Liu, Jun
AU - Zhang, Chen
AU - Duan, Chenchi
AU - Zhang, Hanqiu
AU - Mol, Ben W.
AU - Dennis, Cindy Lee
AU - Yin, Tailang
AU - Yang, Jing
AU - Huang, Hefeng
PY - 2020/8/1
Y1 - 2020/8/1
N2 - OBJECTIVE: To assess whether vaginal secretions and breast milk of COVID-19 patients contain SARS-CoV-2 virus. DESIGN: Single center cohort study. SETTING: Renmin Hospital of Wuhan University, Wuhan, Hubei province, China. POPULATION OR SAMPLE: We studied 13 COVID-19 infected pregnant women diagnosed between January 31 and March 9, 2020. METHODS: We collected clinical data, vaginal secretions and stool specimens, breast milk from COVID-19 infected women during different stages of pregnancy and neonatal throat, anal swabs. MAIN OUTCOME(S) AND MEASURE(S): We assessed viral presence in different biosamples. RESULTS: Of the 13 women with COVID-19, 5 were in their first trimester, 3 in their second trimester, and 5 in their third trimester. Of the 5 women during their third trimester who gave birth, all delivered live newborns. Among these 5 deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of 9 stool samples was positive; and all 13 vaginal secretion samples, and 5 throat swabs and 4 anal swabs collected from newborns were negative for the novel coronavirus. However, 1 of 3 samples of breast milk was positive by viral nucleic acid testing. CONCLUSIONS: In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination.
AB - OBJECTIVE: To assess whether vaginal secretions and breast milk of COVID-19 patients contain SARS-CoV-2 virus. DESIGN: Single center cohort study. SETTING: Renmin Hospital of Wuhan University, Wuhan, Hubei province, China. POPULATION OR SAMPLE: We studied 13 COVID-19 infected pregnant women diagnosed between January 31 and March 9, 2020. METHODS: We collected clinical data, vaginal secretions and stool specimens, breast milk from COVID-19 infected women during different stages of pregnancy and neonatal throat, anal swabs. MAIN OUTCOME(S) AND MEASURE(S): We assessed viral presence in different biosamples. RESULTS: Of the 13 women with COVID-19, 5 were in their first trimester, 3 in their second trimester, and 5 in their third trimester. Of the 5 women during their third trimester who gave birth, all delivered live newborns. Among these 5 deliveries, the primary adverse perinatal outcomes included premature delivery (n = 2) and neonatal pneumonia (n = 2). One of 9 stool samples was positive; and all 13 vaginal secretion samples, and 5 throat swabs and 4 anal swabs collected from newborns were negative for the novel coronavirus. However, 1 of 3 samples of breast milk was positive by viral nucleic acid testing. CONCLUSIONS: In this case series of 13 pregnant women with COVID-19, we observed negative viral test results in vaginal secretion specimens, suggesting that a vaginal delivery may be a safe delivery option. However, additional research is urgently needed to examine breast milk and the potential risk for viral contamination.
KW - breast milk
KW - COVID-19
KW - vaginal secretions
UR - http://www.scopus.com/inward/record.url?scp=85084616782&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.16276
DO - 10.1111/1471-0528.16276
M3 - Article
C2 - 32369656
AN - SCOPUS:85084616782
SN - 1470-0328
VL - 127
SP - 1109
EP - 1115
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 9
ER -