Coreceptors and HIV-1 pathogenesis

Paul R. Gorry, Petronela Ancuta

Research output: Contribution to journalReview ArticleOtherpeer-review

91 Citations (Scopus)

Abstract

The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference as well as the efficiency and mechanism of interaction between HIV-1 and CCR5 and/or CXCR4 has a significant influence on viral tropism, progression of disease, and response to coreceptor antagonists. In addition, these alterations influence the susceptibility of CD4+ T-cell, monocyte, and dendritic cell subsets to infection and therefore, are important for several facets of HIV-1 pathogenesis including the establishment of latent reservoirs, trafficking, and transmission. This review highlights recent literature that has advanced our understanding of the role of coreceptors in HIV-1 pathogenesis.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalCurrent HIV/AIDS Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Mar 2011

Keywords

  • CCR5
  • CD4+ T cells
  • Coreceptors
  • CXCR4
  • Dendritic cells
  • HIV-1
  • Macrophages
  • Monocytes
  • Pathogenesis
  • Reservoirs
  • Tropism

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