Core degradable star RAFT polymers: Synthesis, polymerization, and degradation studies

Julien Rosselgong; Elizabeth G L Williams; Tam P. Le; Felix A. Grusche; Tracey M Hinton; Mark L Tizard; Pathiraja Gunatillake; San H. Thang

doi:10.1021/ma402122z

Core degradable star RAFT polymers: Synthesis, polymerization, and degradation studies

Julien Rosselgong, Elizabeth G L Williams, Tam P. Le, Felix A. Grusche, Tracey M Hinton, Mark L Tizard, Pathiraja Gunatillake, San H. Thang

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

This study reports on the synthesis and characterization of a novel four-arm reagent and its use in the synthesis of core degradable star polymers and block copolymers using the reversible addition-fragmentation chain transfer (RAFT) polymerization process. The star RAFT polymers prepared from methyl methacrylate (MMA), styrene (ST) and N,N-dimethylacrylamide (DMA) were characterized by size exclusion chromatography (SEC). The PMMA star polymer was further polymerized with poly(ethylene glycol) methyl ether methacrylate (POEGMA_8-9) to produce a star block copolymer. The core degradability of the star polymers (PMMA₄₀)₄, (PMMA₈₀) _4, (PS₄₀)₄, (PS₈₀)₄ and star block copolymer P[MMA₄₆-b-(POEGMA_8-9) ₄₆]₄ under reductive conditions to cleave the disulfide linkages was demonstrated. The results demonstrated the complete degradation of the star polymer to produce linear polymer and confirmed the near equal degree of polymerization in each of the arms. The star polymer (PDMA₈₀) ₄ degraded slowly under acidic and enzymatic conditions demonstrating that the ester linkage can also be degraded.

Original language	English
Pages (from-to)	9181-9188
Number of pages	8
Journal	Macromolecules
Volume	46
Issue number	23
DOIs	https://doi.org/10.1021/ma402122z
Publication status	Published - 10 Dec 2013
Externally published	Yes

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10.1021/ma402122z

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title = "Core degradable star RAFT polymers: Synthesis, polymerization, and degradation studies",

abstract = "This study reports on the synthesis and characterization of a novel four-arm reagent and its use in the synthesis of core degradable star polymers and block copolymers using the reversible addition-fragmentation chain transfer (RAFT) polymerization process. The star RAFT polymers prepared from methyl methacrylate (MMA), styrene (ST) and N,N-dimethylacrylamide (DMA) were characterized by size exclusion chromatography (SEC). The PMMA star polymer was further polymerized with poly(ethylene glycol) methyl ether methacrylate (POEGMA8-9) to produce a star block copolymer. The core degradability of the star polymers (PMMA40)4, (PMMA80) 4, (PS40)4, (PS80)4 and star block copolymer P[MMA46-b-(POEGMA8-9) 46]4 under reductive conditions to cleave the disulfide linkages was demonstrated. The results demonstrated the complete degradation of the star polymer to produce linear polymer and confirmed the near equal degree of polymerization in each of the arms. The star polymer (PDMA80) 4 degraded slowly under acidic and enzymatic conditions demonstrating that the ester linkage can also be degraded.",

author = "Julien Rosselgong and Williams, {Elizabeth G L} and Le, {Tam P.} and Grusche, {Felix A.} and Hinton, {Tracey M} and Tizard, {Mark L} and Pathiraja Gunatillake and Thang, {San H.}",

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T2 - Synthesis, polymerization, and degradation studies

AU - Rosselgong, Julien

AU - Williams, Elizabeth G L

AU - Le, Tam P.

AU - Grusche, Felix A.

AU - Hinton, Tracey M

AU - Tizard, Mark L

AU - Gunatillake, Pathiraja

AU - Thang, San H.

PY - 2013/12/10

Y1 - 2013/12/10

N2 - This study reports on the synthesis and characterization of a novel four-arm reagent and its use in the synthesis of core degradable star polymers and block copolymers using the reversible addition-fragmentation chain transfer (RAFT) polymerization process. The star RAFT polymers prepared from methyl methacrylate (MMA), styrene (ST) and N,N-dimethylacrylamide (DMA) were characterized by size exclusion chromatography (SEC). The PMMA star polymer was further polymerized with poly(ethylene glycol) methyl ether methacrylate (POEGMA8-9) to produce a star block copolymer. The core degradability of the star polymers (PMMA40)4, (PMMA80) 4, (PS40)4, (PS80)4 and star block copolymer P[MMA46-b-(POEGMA8-9) 46]4 under reductive conditions to cleave the disulfide linkages was demonstrated. The results demonstrated the complete degradation of the star polymer to produce linear polymer and confirmed the near equal degree of polymerization in each of the arms. The star polymer (PDMA80) 4 degraded slowly under acidic and enzymatic conditions demonstrating that the ester linkage can also be degraded.

AB - This study reports on the synthesis and characterization of a novel four-arm reagent and its use in the synthesis of core degradable star polymers and block copolymers using the reversible addition-fragmentation chain transfer (RAFT) polymerization process. The star RAFT polymers prepared from methyl methacrylate (MMA), styrene (ST) and N,N-dimethylacrylamide (DMA) were characterized by size exclusion chromatography (SEC). The PMMA star polymer was further polymerized with poly(ethylene glycol) methyl ether methacrylate (POEGMA8-9) to produce a star block copolymer. The core degradability of the star polymers (PMMA40)4, (PMMA80) 4, (PS40)4, (PS80)4 and star block copolymer P[MMA46-b-(POEGMA8-9) 46]4 under reductive conditions to cleave the disulfide linkages was demonstrated. The results demonstrated the complete degradation of the star polymer to produce linear polymer and confirmed the near equal degree of polymerization in each of the arms. The star polymer (PDMA80) 4 degraded slowly under acidic and enzymatic conditions demonstrating that the ester linkage can also be degraded.

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JO - Macromolecules

JF - Macromolecules

SN - 0024-9297

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ER -

Core degradable star RAFT polymers: Synthesis, polymerization, and degradation studies

Abstract

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