Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P. M. Royce; J. Camakaris; J. R. Mann; D. M. Danks

doi:10.1042/bj2020369

Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P. M. Royce, J. Camakaris, J. R. Mann, D. M. Danks

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Abstract

Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu⁺ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

Original language	English
Pages (from-to)	369-371
Number of pages	3
Journal	Biochemical Journal
Volume	202
Issue number	2
DOIs	https://doi.org/10.1042/bj2020369
Publication status	Published - 1982
Externally published	Yes

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title = "Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice",

abstract = "Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60\% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150\% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.",

author = "Royce, \{P. M.\} and J. Camakaris and Mann, \{J. R.\} and Danks, \{D. M.\}",

year = "1982",

doi = "10.1042/bj2020369",

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journal = "Biochemical Journal",

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AU - Royce, P. M.

AU - Camakaris, J.

AU - Mann, J. R.

AU - Danks, D. M.

PY - 1982

Y1 - 1982

N2 - Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

AB - Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

UR - https://www.scopus.com/pages/publications/0020064391

U2 - 10.1042/bj2020369

DO - 10.1042/bj2020369

M3 - Article

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SN - 0264-6021

VL - 202

SP - 369

EP - 371

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

Abstract

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