Abstract
Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.
| Original language | English |
|---|---|
| Pages (from-to) | 369-371 |
| Number of pages | 3 |
| Journal | Biochemical Journal |
| Volume | 202 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1982 |
| Externally published | Yes |
Cite this
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Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice. / Royce, P. M.; Camakaris, J.; Mann, J. R.; Danks, D. M.
In: Biochemical Journal, Vol. 202, No. 2, 1982, p. 369-371.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice
AU - Royce, P. M.
AU - Camakaris, J.
AU - Mann, J. R.
AU - Danks, D. M.
PY - 1982
Y1 - 1982
N2 - Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.
AB - Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.
UR - http://www.scopus.com/inward/record.url?scp=0020064391&partnerID=8YFLogxK
U2 - 10.1042/bj2020369
DO - 10.1042/bj2020369
M3 - Article
VL - 202
SP - 369
EP - 371
JO - Biochemical Journal
JF - Biochemical Journal
SN - 0264-6021
IS - 2
ER -