Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P. M. Royce, J. Camakaris, J. R. Mann, D. M. Danks

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Abstract

Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

Original languageEnglish
Pages (from-to)369-371
Number of pages3
JournalBiochemical Journal
Volume202
Issue number2
DOIs
Publication statusPublished - 1982
Externally publishedYes

Cite this

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Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice. / Royce, P. M.; Camakaris, J.; Mann, J. R.; Danks, D. M.

In: Biochemical Journal, Vol. 202, No. 2, 1982, p. 369-371.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

AU - Royce, P. M.

AU - Camakaris, J.

AU - Mann, J. R.

AU - Danks, D. M.

PY - 1982

Y1 - 1982

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AB - Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

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