Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P. M. Royce; J. Camakaris; J. R. Mann; D. M. Danks

doi:10.1042/bj2020369

Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P. M. Royce, J. Camakaris, J. R. Mann, D. M. Danks

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Abstract

Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu⁺ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

Original language	English
Pages (from-to)	369-371
Number of pages	3
Journal	Biochemical Journal
Volume	202
Issue number	2
DOIs	https://doi.org/10.1042/bj2020369
Publication status	Published - 1982
Externally published	Yes

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10.1042/bj2020369

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title = "Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice",

abstract = "Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.",

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year = "1982",

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AU - Royce, P. M.

AU - Camakaris, J.

AU - Mann, J. R.

AU - Danks, D. M.

PY - 1982

Y1 - 1982

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AB - Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

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