Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice

P. M. Royce, J. Camakaris, J. R. Mann, D. M. Danks

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)


Lysyl oxidase activity in extracts of skin from 10-day-old Mo[br]/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mo[br]/Y mice at 7 days of age with a single subcutaneous injection of 50 μg of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes.

Original languageEnglish
Pages (from-to)369-371
Number of pages3
JournalBiochemical Journal
Issue number2
Publication statusPublished - 1982
Externally publishedYes

Cite this