Copper-catalyzed preparation of g-alkylidenebutenolides and isocoumarins under mild palladium-free conditions

Samuel Inack-Ngi, Raphael Steve Rahmani, Laurent Commeiras, Gaelle Chouraqui, Jerome Thibonnet, Alain Duchene, Mohamed Abarbri, Jean-Luc Parrain

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A general and efficient copper(I)-catalyzed cross-coupling and heterocyclization reaction of terminal alkynes and ?-iodo-a,?- unsaturated acid derivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5-ylidenebutenolides and 3-substituted isocoumarins with excellent regio- and stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.
Original languageEnglish
Pages (from-to)779 - 788
Number of pages10
JournalAdvanced Synthesis and Catalysis
Issue number5
Publication statusPublished - 2009
Externally publishedYes

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