Copper-catalyzed oxidative cross-coupling of sulfoximines and alkynes

Long Wang, He Huang, Daniel Priebbenow, Fangfang Pan, Carsten Bolm

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118 Citations (Scopus)


A Cu te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines.
Original languageEnglish
Pages (from-to)3478 - 3480
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number12
Publication statusPublished - 2013
Externally publishedYes

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