Copper-catalyzed oxidative cross-coupling of sulfoximines and alkynes

Long Wang; He Huang; Daniel Priebbenow; Fangfang Pan; Carsten Bolm

doi:10.1002/anie.201209975

Copper-catalyzed oxidative cross-coupling of sulfoximines and alkynes

Long Wang, He Huang, Daniel Priebbenow, Fangfang Pan, Carsten Bolm

Research output: Contribution to journal › Article › Research › peer-review

125 Citations (Scopus)

Abstract

A Cu te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines.

Original language	English
Pages (from-to)	3478 - 3480
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	12
DOIs	https://doi.org/10.1002/anie.201209975
Publication status	Published - 2013
Externally published	Yes

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10.1002/anie.201209975

Cite this

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title = "Copper-catalyzed oxidative cross-coupling of sulfoximines and alkynes",

abstract = "A Cu te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines.",

author = "Long Wang and He Huang and Daniel Priebbenow and Fangfang Pan and Carsten Bolm",

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AU - Huang, He

AU - Priebbenow, Daniel

AU - Pan, Fangfang

AU - Bolm, Carsten

PY - 2013

Y1 - 2013

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AB - A Cu te couple: A synthetically useful protocol for the preparation of N-alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper-catalyzed oxidative cross-coupling of NH-sulfoximines and terminal alkynes (see scheme). The corresponding N-acyl sulfoximines were also obtained selectively after acid-catalyzed hydrolysis of the yne sulfoximines.

U2 - 10.1002/anie.201209975

DO - 10.1002/anie.201209975

M3 - Article

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VL - 52

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EP - 3480

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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