Copper-catalyzed [4 + 2] annulation reaction of ß-enaminones and aryl diazonium salts without external oxidant: Synthesis of highly functionalized 3: H -1,2,4-triazines via homogeneous or heterogeneous strategy

Qifeng Ding, Mingrui Li, Yiming Sun, Yang Yu, Jonathan B. Baell, Fei Huang

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15 Citations (Scopus)


Herein, both homogeneous and heterogeneous strategies were developed to access highly functionalized 3H-1,2,4-triazines using Cu-catalyzed [4 + 2] annulation. This new protocol featured external oxidant-free conditions, a non-noble copper catalyst and good functional group compatibility. The multiple valence states of copper were further confirmed by X-ray photoelectron spectroscopy.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalOrganic Chemistry Frontiers
Issue number3
Publication statusPublished - 7 Feb 2020

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