Copper and Molecular Aspects of Cell Signaling

A Grubman, A.R. White

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Copper is an essential dietary element. Because of its potent redox activity and high affinity for biomolecules, cellular copper metabolism has been traditionally regarded as a series of protein shuttles to a final destination buried deep within protein active sites to prevent toxicity. Several decades of evidence have now established exogenous copper as a modulator of cell signaling, demonstrating that copper can serve as a signal itself and can potentiate or block signaling at multiple points in subcellular and intercellular signal transduction pathways. More recently, emerging evidence shows that copper is an important endogenous regulator of cell signaling, through mobilization of labile metal ions from existing cellular stores, which can affect diverse processes including cell proliferation, tumorigenesis, and neurotransmission. This chapter will describe the current state of knowledge on the role of copper in signal transduction with a focus on mechanisms mediated by direct copper interactions with cellular targets.

Original languageEnglish
Title of host publicationMolecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
EditorsJames F. Collins
Place of PublicationLondon UK
PublisherElsevier
Pages85-99
Number of pages15
ISBN (Electronic)9780128023761
ISBN (Print)9780128021682
DOIs
Publication statusPublished - 29 Sep 2016
Externally publishedYes

Publication series

NameMolecular Nutrition
PublisherAcademic Press

Keywords

  • Copper
  • DNA methylation
  • GABA receptor
  • Glutamate receptor
  • Growth factor receptor signaling
  • Histone modification
  • Mitogen-associated protein kinase
  • Neurotransmission
  • Signal transduction

Cite this

Grubman, A., & White, A. R. (2016). Copper and Molecular Aspects of Cell Signaling. In J. F. Collins (Ed.), Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals (pp. 85-99). (Molecular Nutrition). London UK: Elsevier. https://doi.org/10.1016/B978-0-12-802168-2.00008-7
Grubman, A ; White, A.R. / Copper and Molecular Aspects of Cell Signaling. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. editor / James F. Collins. London UK : Elsevier, 2016. pp. 85-99 (Molecular Nutrition).
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Grubman, A & White, AR 2016, Copper and Molecular Aspects of Cell Signaling. in JF Collins (ed.), Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Molecular Nutrition, Elsevier, London UK, pp. 85-99. https://doi.org/10.1016/B978-0-12-802168-2.00008-7

Copper and Molecular Aspects of Cell Signaling. / Grubman, A; White, A.R.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. ed. / James F. Collins. London UK : Elsevier, 2016. p. 85-99 (Molecular Nutrition).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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AB - Copper is an essential dietary element. Because of its potent redox activity and high affinity for biomolecules, cellular copper metabolism has been traditionally regarded as a series of protein shuttles to a final destination buried deep within protein active sites to prevent toxicity. Several decades of evidence have now established exogenous copper as a modulator of cell signaling, demonstrating that copper can serve as a signal itself and can potentiate or block signaling at multiple points in subcellular and intercellular signal transduction pathways. More recently, emerging evidence shows that copper is an important endogenous regulator of cell signaling, through mobilization of labile metal ions from existing cellular stores, which can affect diverse processes including cell proliferation, tumorigenesis, and neurotransmission. This chapter will describe the current state of knowledge on the role of copper in signal transduction with a focus on mechanisms mediated by direct copper interactions with cellular targets.

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Grubman A, White AR. Copper and Molecular Aspects of Cell Signaling. In Collins JF, editor, Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. London UK: Elsevier. 2016. p. 85-99. (Molecular Nutrition). https://doi.org/10.1016/B978-0-12-802168-2.00008-7