Coordinating TLR-activated signaling pathways in cells of the immune system

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Abstract

Toll-like receptor (TLR) signaling leads to the activation of mitogen-activated protein kinase and nuclear factor-κB signaling pathways. While the upstream signaling events initiated at the level of adaptors and the activation of the downstream signaling pathways have received a lot of attention, our understanding of how these signaling pathways are coordinated to regulate gene expression is poorly understood. This review gives a selective overview on our current understanding of signaling downstream of TLRs, with an emphasis on how the upstream kinases like the mitogen-activated protein kinase kinase kinases (TAK1 and Tpl2) and inhibitor of κ-B kinase (IKK) coordinate the signaling events that steer the course of an immune response.

Original languageEnglish
Pages (from-to)420-424
Number of pages5
JournalImmunology and Cell Biology
Volume85
Issue number6
DOIs
Publication statusPublished - 1 Aug 2007
Externally publishedYes

Keywords

  • ERK
  • Gene regulation
  • NF-κB
  • TLR signaling
  • Tpl2

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