Coordinating development

how do animals integrate plastic and robust developmental processes?

Christen Kerry Mirth, Alexander Shingleton

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Our developmental environment significantly affects myriad aspects of our biology, including key life history traits, morphology, physiology, and our susceptibility to disease. This environmentally-induced variation in phenotype is known as plasticity. In many cases, plasticity results from alterations in the rate of synthesis of important developmental hormones. However, while developmental processes like organ growth are sensitive to environmental conditions, others like patterning – the process that generates distinct cell identities – remain robust to perturbation. This is particularly surprising given that the same hormones that regulate organ growth also regulate organ patterning. In this review, we revisit the current approaches that address how organs coordinate their growth and pattern, and outline our hypotheses for understanding how organs achieve correct pattern across a range of sizes.
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalFrontiers in Cell and Developmental Biology
Volume7
Issue number8
DOIs
Publication statusPublished - 6 Feb 2019

Cite this

@article{f38e7e7631ff4bd282331f28d2bb728d,
title = "Coordinating development: how do animals integrate plastic and robust developmental processes?",
abstract = "Our developmental environment significantly affects myriad aspects of our biology, including key life history traits, morphology, physiology, and our susceptibility to disease. This environmentally-induced variation in phenotype is known as plasticity. In many cases, plasticity results from alterations in the rate of synthesis of important developmental hormones. However, while developmental processes like organ growth are sensitive to environmental conditions, others like patterning – the process that generates distinct cell identities – remain robust to perturbation. This is particularly surprising given that the same hormones that regulate organ growth also regulate organ patterning. In this review, we revisit the current approaches that address how organs coordinate their growth and pattern, and outline our hypotheses for understanding how organs achieve correct pattern across a range of sizes.",
author = "Mirth, {Christen Kerry} and Alexander Shingleton",
year = "2019",
month = "2",
day = "6",
doi = "10.3389/fcell.2019.00008",
language = "English",
volume = "7",
pages = "1--11",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media",
number = "8",

}

Coordinating development : how do animals integrate plastic and robust developmental processes? / Mirth, Christen Kerry; Shingleton, Alexander.

In: Frontiers in Cell and Developmental Biology, Vol. 7, No. 8, 06.02.2019, p. 1-11.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Coordinating development

T2 - how do animals integrate plastic and robust developmental processes?

AU - Mirth, Christen Kerry

AU - Shingleton, Alexander

PY - 2019/2/6

Y1 - 2019/2/6

N2 - Our developmental environment significantly affects myriad aspects of our biology, including key life history traits, morphology, physiology, and our susceptibility to disease. This environmentally-induced variation in phenotype is known as plasticity. In many cases, plasticity results from alterations in the rate of synthesis of important developmental hormones. However, while developmental processes like organ growth are sensitive to environmental conditions, others like patterning – the process that generates distinct cell identities – remain robust to perturbation. This is particularly surprising given that the same hormones that regulate organ growth also regulate organ patterning. In this review, we revisit the current approaches that address how organs coordinate their growth and pattern, and outline our hypotheses for understanding how organs achieve correct pattern across a range of sizes.

AB - Our developmental environment significantly affects myriad aspects of our biology, including key life history traits, morphology, physiology, and our susceptibility to disease. This environmentally-induced variation in phenotype is known as plasticity. In many cases, plasticity results from alterations in the rate of synthesis of important developmental hormones. However, while developmental processes like organ growth are sensitive to environmental conditions, others like patterning – the process that generates distinct cell identities – remain robust to perturbation. This is particularly surprising given that the same hormones that regulate organ growth also regulate organ patterning. In this review, we revisit the current approaches that address how organs coordinate their growth and pattern, and outline our hypotheses for understanding how organs achieve correct pattern across a range of sizes.

U2 - 10.3389/fcell.2019.00008

DO - 10.3389/fcell.2019.00008

M3 - Review Article

VL - 7

SP - 1

EP - 11

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

IS - 8

ER -