Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance

Dietmar W Hutmacher, Boris M Holzapfel, Elena M De-Juan-Pardo, Brooke A Pereira, Stuart J Ellem, Daniela Loessner, Gail P Risbridger

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

In order to progress beyond currently available medical devices and implants, the concept of tissue engineering has moved into the centre of biomedical research worldwide. The aim of this approach is not to replace damaged tissue with an implant or device but rather to prompt the patient s own tissue to enact a regenerative response by using a tissue-engineered construct to assemble new functional and healthy tissue. More recently, it has been suggested that the combination of Synthetic Biology and translational tissue-engineering techniques could enhance the field of personalized medicine, not only from a regenerative medicine perspective, but also to provide frontier technologies for building and transforming the research landscape in the field of in vitro and in vivo disease models.
Original languageEnglish
Pages (from-to)127 - 132
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume35
DOIs
Publication statusPublished - 2015

Cite this

Hutmacher, Dietmar W ; Holzapfel, Boris M ; De-Juan-Pardo, Elena M ; Pereira, Brooke A ; Ellem, Stuart J ; Loessner, Daniela ; Risbridger, Gail P. / Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance. In: Current Opinion in Biotechnology. 2015 ; Vol. 35. pp. 127 - 132.
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abstract = "In order to progress beyond currently available medical devices and implants, the concept of tissue engineering has moved into the centre of biomedical research worldwide. The aim of this approach is not to replace damaged tissue with an implant or device but rather to prompt the patient s own tissue to enact a regenerative response by using a tissue-engineered construct to assemble new functional and healthy tissue. More recently, it has been suggested that the combination of Synthetic Biology and translational tissue-engineering techniques could enhance the field of personalized medicine, not only from a regenerative medicine perspective, but also to provide frontier technologies for building and transforming the research landscape in the field of in vitro and in vivo disease models.",
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Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance. / Hutmacher, Dietmar W; Holzapfel, Boris M; De-Juan-Pardo, Elena M; Pereira, Brooke A; Ellem, Stuart J; Loessner, Daniela; Risbridger, Gail P.

In: Current Opinion in Biotechnology, Vol. 35, 2015, p. 127 - 132.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ellem, Stuart J

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