Conventional therapy of ulcerative colitis: Corticosteroids

Kirstin Taylor, Peter R. Gibson

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)

Abstract

Corticosteroids are efficacious in patients with active ulcerative colitis, and this, together with their generally low cost, has ensured that they remain an attractive therapeutic option for inducing remission. However, side effects and complications are common, leading to the idea that they are a “necessary evil.” In this chapter, the evidence base for efficacy of various formulations, including oral and topical second-generation corticosteroids, are discussed and complications outlined. Optimal use of corticosteroids (maximizing benefits and minimizing side effects) involves not only the appropriate choice of formulation in specific scenarios, but also sensible management of withdrawal, corticosteroid resistance, and corticosteroid dependence, and institution of strategies to reduce the risks of side effects and complications. The judicious use of corticosteroids should be an integral part of care for all clinicians managing patients with ulcerative colitis.
Original languageEnglish
Title of host publicationCrohn's Disease and Ulcerative Colitis
Subtitle of host publicationFrom Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
EditorsDaniel C Baumgart
Place of PublicationNew York NY USA
PublisherSpringer
Pages399-412
Number of pages14
Edition2nd
ISBN (Electronic)9783319337036
ISBN (Print)9783319337012
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

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