Conventional therapy of ulcerative colitis

Corticosteriods

Kirstin Taylor, Peter R. Gibson

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Corticosteroids are efficacious in patients with active ulcerative colitis, and this, together with their generally low cost, has ensured that they remain an attractive therapeutic option for inducing remission. However, side effects and complications are common, leading to the idea that they are a “necessary evil.” In this chapter, the evidence base for efficacy of various formulations, including oral and topical second-generation corticosteroids, are discussed and complications outlined. Optimal use of corticosteroids (maximizing benefits and minimizing side effects) involves not only the appropriate choice of formulation in specific scenarios, but also sensible management of withdrawal, corticosteroid resistance, and corticosteroid dependence, and institution of strategies to reduce the risks of side effects and complications. The judicious use of corticosteroids should be an integral part of care for all clinicians managing patients with ulcerative colitis.
Original languageEnglish
Title of host publicationCrohn's Disease and Ulcerative Colitis
Subtitle of host publicationFrom Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
EditorsDaniel C Baumgart
Place of PublicationNew York NY USA
PublisherSpringer
Pages399 - 412
Number of pages14
Edition2nd
ISBN (Electronic)978-3-319-33703-6
ISBN (Print)978-3-319-33701-2
DOIs
Publication statusPublished - 2017

Cite this

Taylor, K., & Gibson, P. R. (2017). Conventional therapy of ulcerative colitis: Corticosteriods. In D. C. Baumgart (Ed.), Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach (2nd ed., pp. 399 - 412). New York NY USA: Springer. https://doi.org/10.1007/978-3-319-33703-6_39
Taylor, Kirstin ; Gibson, Peter R. / Conventional therapy of ulcerative colitis : Corticosteriods. Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. editor / Daniel C Baumgart. 2nd. ed. New York NY USA : Springer, 2017. pp. 399 - 412
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Taylor, K & Gibson, PR 2017, Conventional therapy of ulcerative colitis: Corticosteriods. in DC Baumgart (ed.), Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. 2nd edn, Springer, New York NY USA, pp. 399 - 412. https://doi.org/10.1007/978-3-319-33703-6_39

Conventional therapy of ulcerative colitis : Corticosteriods. / Taylor, Kirstin; Gibson, Peter R.

Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. ed. / Daniel C Baumgart. 2nd. ed. New York NY USA : Springer, 2017. p. 399 - 412.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Taylor K, Gibson PR. Conventional therapy of ulcerative colitis: Corticosteriods. In Baumgart DC, editor, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. 2nd ed. New York NY USA: Springer. 2017. p. 399 - 412 https://doi.org/10.1007/978-3-319-33703-6_39