Controversies in granzyme biology

O. Susanto, J. A. Trapani, D. Brasacchio

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45 Citations (Scopus)


Granzymes (Grz) are a family of serine proteases found in the granules of cytotoxic lymphocytes and are emerging as an important group of proteins involved in immune function and surveillance. Grz have both cytotoxic and more recently reported non-cytotoxic roles, however these functions are still subject to thorough investigation. The significance of the cytotoxic and importantly the non-cytotoxic roles of Grz will be discussed in this review, detailing accepted and controversial functions.

Original languageEnglish
Pages (from-to)477-487
Number of pages11
JournalTissue Antigens
Issue number6
Publication statusPublished - Dec 2012
Externally publishedYes


  • Cell death
  • Cytotoxic lymphocytes
  • Granzymes

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