TY - JOUR
T1 - Controlling vector-borne diseases by releasing modified mosquitoes
AU - Flores, Heather A.
AU - O'Neill, Scott L.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are becoming major global health emergencies while old threats, such as yellow fever, are re-emerging. Traditional control methods, which have focused on reducing mosquito populations through the application of insecticides or preventing breeding through removal of larval habitat, are largely ineffective, as evidenced by the increasing global disease burden. Here, we review novel mosquito population reduction and population modification approaches with a focus on control methods based on the release of mosquitoes, including the release of Wolbachia-infected mosquitoes and strategies to genetically modify the vector, that are currently under development and have the potential to contribute to a reversal of the current alarming disease trends.
AB - Aedes mosquito-transmitted diseases, such as dengue, Zika and chikungunya, are becoming major global health emergencies while old threats, such as yellow fever, are re-emerging. Traditional control methods, which have focused on reducing mosquito populations through the application of insecticides or preventing breeding through removal of larval habitat, are largely ineffective, as evidenced by the increasing global disease burden. Here, we review novel mosquito population reduction and population modification approaches with a focus on control methods based on the release of mosquitoes, including the release of Wolbachia-infected mosquitoes and strategies to genetically modify the vector, that are currently under development and have the potential to contribute to a reversal of the current alarming disease trends.
UR - http://www.scopus.com/inward/record.url?scp=85047112829&partnerID=8YFLogxK
U2 - 10.1038/s41579-018-0025-0
DO - 10.1038/s41579-018-0025-0
M3 - Review Article
C2 - 29777177
AN - SCOPUS:85047112829
VL - 16
SP - 508
EP - 518
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 8
ER -