Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly

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Abstract

Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.

Original languageEnglish
Number of pages22
JournalMacromolecular Rapid Communications
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Keywords

  • biomedical applications
  • dispersion polymerization
  • emulsion polymerization
  • polymerization-induced self-assembly
  • reversible addition-fragmentation chain transfer

Cite this

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title = "Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly",
abstract = "Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.",
keywords = "biomedical applications, dispersion polymerization, emulsion polymerization, polymerization-induced self-assembly, reversible addition-fragmentation chain transfer",
author = "Khor, {Song Yang} and Quinn, {John F.} and Whittaker, {Michael R.} and Truong, {Nghia P.} and Davis, {Thomas P.}",
year = "2018",
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doi = "10.1002/marc.201800438",
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T1 - Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly

AU - Khor, Song Yang

AU - Quinn, John F.

AU - Whittaker, Michael R.

AU - Truong, Nghia P.

AU - Davis, Thomas P.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.

AB - Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.

KW - biomedical applications

KW - dispersion polymerization

KW - emulsion polymerization

KW - polymerization-induced self-assembly

KW - reversible addition-fragmentation chain transfer

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