Abstract
Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.
| Original language | English |
|---|---|
| Article number | 1800438 |
| Number of pages | 22 |
| Journal | Macromolecular Rapid Communications |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 2019 |
Keywords
- biomedical applications
- dispersion polymerization
- emulsion polymerization
- polymerization-induced self-assembly
- reversible addition-fragmentation chain transfer
Cite this
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Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly. / Khor, Song Yang; Quinn, John F.; Whittaker, Michael R.; Truong, Nghia P.; Davis, Thomas P.
In: Macromolecular Rapid Communications, Vol. 40, No. 2, 1800438, 01.2019.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly
AU - Khor, Song Yang
AU - Quinn, John F.
AU - Whittaker, Michael R.
AU - Truong, Nghia P.
AU - Davis, Thomas P.
PY - 2019/1
Y1 - 2019/1
N2 - Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.
AB - Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.
KW - biomedical applications
KW - dispersion polymerization
KW - emulsion polymerization
KW - polymerization-induced self-assembly
KW - reversible addition-fragmentation chain transfer
UR - http://www.scopus.com/inward/record.url?scp=85052397785&partnerID=8YFLogxK
U2 - 10.1002/marc.201800438
DO - 10.1002/marc.201800438
M3 - Article
AN - SCOPUS:85052397785
VL - 40
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
SN - 1022-1336
IS - 2
M1 - 1800438
ER -