Controlled Delivery of Levothyroxine Using Porous Silicon as a Drug Nanocontainer

Soheila Kashanian; Elham Rostami; Frances J. Harding; Steven J P McInnes; Sameer Al-Bataineh; Nicolas H. Voelcker

doi:10.1071/CH15315

Controlled Delivery of Levothyroxine Using Porous Silicon as a Drug Nanocontainer

Soheila Kashanian, Elham Rostami, Frances J. Harding, Steven J P McInnes, Sameer Al-Bataineh, Nicolas H. Voelcker

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50% and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.

Original language	English
Pages (from-to)	204-211
Number of pages	8
Journal	Australian Journal of Chemistry
Volume	69
Issue number	2
DOIs	https://doi.org/10.1071/CH15315
Publication status	Published - 2016
Externally published	Yes

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10.1071/CH15315

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abstract = "Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50% and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.",

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AU - Kashanian, Soheila

AU - Rostami, Elham

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AU - McInnes, Steven J P

AU - Al-Bataineh, Sameer

AU - Voelcker, Nicolas H.

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N2 - Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50% and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.

AB - Porous silicon (pSi) materials are regarded as promising drug delivery vehicles due to their biocompatibility, in vivo degradation, and resorption. We examine pSi films as a platform for the controlled delivery of levothyroxine, as a means to overcome problems with consistent dosage of this drug by oral administration. Oxidized pSi films were modified with 3-(aminopropyl)triethoxysilane (APTES), creating a surface chemistry that increased levothyroxine drug loading capacity by 50% and sustained drug release under physiological conditions for 14 days. Release kinetics from APTES-functionalized films initially followed a zero-order release profile, which is highly desirable for drug delivery. The loading and release profiles of levothyroxine suggest that the film size required to deliver a therapeutic dose is feasible for further consideration as an implantable delivery system.

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Controlled Delivery of Levothyroxine Using Porous Silicon as a Drug Nanocontainer

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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Controlled Delivery of Levothyroxine Using Porous Silicon as a Drug Nanocontainer

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