Controlled alternate layer-by-layer assembly of lectins and glycopolymers using QCM-D

Yanzi Gou, Stacy Slavin, Jin Geng, Lenny Voorhaar, David M. Haddleton, C. Remzi Becer

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31 Citations (Scopus)

Abstract

Layer-by-layer (LBL) assembly of concanavalin A (Con A), peanut agglutinin (PNA) plant lectins, and welldefined synthetic glycopolymers via their biological affinities have been prepared using a quartz crystal microbalance with dissipation monitoring (QCM-D). We demonstrate the use of mannose/galactose glycopolymers as lectin binders due to their selective binding to Con A/PNA, respectively. A detailed analysis of the adsorption processes and the adsorbed layer are provided and tuning the composition of multilayers using a series of well-defined glycopolymers differing only in the pendant sugar ratio is discussed.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalACS Macro Letters
Volume1
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Cite this

Gou, Y., Slavin, S., Geng, J., Voorhaar, L., Haddleton, D. M., & Becer, C. R. (2012). Controlled alternate layer-by-layer assembly of lectins and glycopolymers using QCM-D. ACS Macro Letters, 1(1), 180-183. https://doi.org/10.1021/mz200063r