Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

Jun-Bing Fan, Yongyang Song, Hongfu Li, Jin-Peng Jia, Xinglin Guo, Lei Jiang

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Control of the stretching or compressing ratio of spherical nanoparticles (NPs) leads to a dramatic change in the shape and size of particles based on amphiphilic biodegradable poly(lactide-co-glycolide-b-ethylene glycol-b-lactide-co-glycolide) (PLGE) triblock copolymers. Drug release, endocytosis and intracellular accumulation tests on these anisotropic PLGE NPs show significantly enhanced properties in comparison with spherical NPs, indicating they are good candidates for drug delivery.

Original languageEnglish
Pages (from-to)3911-3914
Number of pages4
JournalJournal of Materials Chemistry B
Volume2
Issue number25
DOIs
Publication statusPublished - 7 Jul 2014
Externally publishedYes

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