Control of electrical and calcium alternans in a one-dimensional cardiac cable

Jin Keong; Boon Leong Lan; Einly Lim; Duy Manh Le; Shiuan Ni Liang

doi:10.1007/978-981-99-7243-2_36

Control of electrical and calcium alternans in a one-dimensional cardiac cable

Jin Keong, Boon Leong Lan, Einly Lim, Duy Manh Le, Shiuan Ni Liang

Malaysia School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

Abstract

Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and thus, affect the effectiveness of controlling alternans. In this study, the control of cardiac alternans in a one-dimensional short cable was investigated numerically using the T± ϵ feedback control, where T is the basic cycle length and ϵ is a pre-set control parameter. The effectiveness of controlling alternans between action potential duration (APD) and peak value of intracellular calcium concentration (peak-[Ca]) being used as the feedback control variables were compared. Results showed that the effectiveness of APD-based and Ca-based feedback controls were the same when ϵ was less than the critical value (ϵ_c ), however, the APD-based control performed better than the Ca-based feedback control when ϵ> ϵ_c. This study may improve the understanding of which method is a better feedback control and lead to the development of a better alternans control scheme.

Original language	English
Title of host publication	22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II
Editors	Fazilah Hassan, Noorhazirah Sunar, Mohd Ariffanan Mohd Basri, Mohd Saiful Azimi Mahmud, Mohamad Hafis Izran Ishak, Mohamed Sultan Mohamed Ali
Place of Publication	Singapore Singapore
Publisher	Springer
Pages	441-451
Number of pages	11
Edition	1st
ISBN (Electronic)	9789819972432
ISBN (Print)	9789819972425
DOIs	https://doi.org/10.1007/978-981-99-7243-2_36
Publication status	Published - 2024
Event	Asia Simulation Conference 2023 - Langkawi, Malaysia Duration: 25 Oct 2023 → 26 Oct 2023 Conference number: 22nd https://link.springer.com/book/10.1007/978-981-99-7243-2 (Proceedings) https://mysimsc.org/asiasim2023/ (Website)

Publication series

Name	Communications in Computer and Information Science
Publisher	Springer
Volume	1912
ISSN (Print)	1865-0929
ISSN (Electronic)	1865-0937

Conference

Conference	Asia Simulation Conference 2023
Abbreviated title	AsiaSim 2023
Country/Territory	Malaysia
City	Langkawi
Period	25/10/23 → 26/10/23
Internet address	https://link.springer.com/book/10.1007/978-981-99-7243-2 (Proceedings) https://mysimsc.org/asiasim2023/ (Website)

Keywords

Nonlinear dynamics and chaos
Cardiac dynamics
Feedback control
Applications of chaos

Access to Document

10.1007/978-981-99-7243-2_36

Cite this

Keong, J., Lan, B. L., Lim, E., Le, D. M., & Liang, S. N. (2024). Control of electrical and calcium alternans in a one-dimensional cardiac cable. In F. Hassan, N. Sunar, M. A. Mohd Basri, M. S. A. Mahmud, M. H. I. Ishak, & M. S. Mohamed Ali (Eds.), 22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II (1st ed., pp. 441-451). (Communications in Computer and Information Science; Vol. 1912). Springer. https://doi.org/10.1007/978-981-99-7243-2_36

Keong, Jin ; Lan, Boon Leong ; Lim, Einly et al. / Control of electrical and calcium alternans in a one-dimensional cardiac cable. 22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II. editor / Fazilah Hassan ; Noorhazirah Sunar ; Mohd Ariffanan Mohd Basri ; Mohd Saiful Azimi Mahmud ; Mohamad Hafis Izran Ishak ; Mohamed Sultan Mohamed Ali. 1st. ed. Singapore Singapore : Springer, 2024. pp. 441-451 (Communications in Computer and Information Science).

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title = "Control of electrical and calcium alternans in a one-dimensional cardiac cable",

abstract = "Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and thus, affect the effectiveness of controlling alternans. In this study, the control of cardiac alternans in a one-dimensional short cable was investigated numerically using the T± ϵ feedback control, where T is the basic cycle length and ϵ is a pre-set control parameter. The effectiveness of controlling alternans between action potential duration (APD) and peak value of intracellular calcium concentration (peak-[Ca]) being used as the feedback control variables were compared. Results showed that the effectiveness of APD-based and Ca-based feedback controls were the same when ϵ was less than the critical value (ϵc ), however, the APD-based control performed better than the Ca-based feedback control when ϵ> ϵc. This study may improve the understanding of which method is a better feedback control and lead to the development of a better alternans control scheme.",

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author = "Jin Keong and Lan, {Boon Leong} and Einly Lim and Le, {Duy Manh} and Liang, {Shiuan Ni}",

note = "Funding Information: Acknowledgements. This work has been supported by the Ministry of Higher Education Malaysia under the Fundamental Research Grant Scheme (FRGS) with project code FRGS/1/2019/STG02/MUSM/03/2. It was also supported in part by the Monash University Malaysia Advanced Computing Platform through the use of the MONTAGE HPC Cluster. Publisher Copyright: {\textcopyright} 2024, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.; Asia Simulation Conference 2023, AsiaSim 2023 ; Conference date: 25-10-2023 Through 26-10-2023",

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Keong, J, Lan, BL, Lim, E, Le, DM & Liang, SN 2024, Control of electrical and calcium alternans in a one-dimensional cardiac cable. in F Hassan, N Sunar, MA Mohd Basri, MSA Mahmud, MHI Ishak & MS Mohamed Ali (eds), 22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II. 1st edn, Communications in Computer and Information Science, vol. 1912, Springer, Singapore Singapore, pp. 441-451, Asia Simulation Conference 2023, Langkawi, Malaysia, 25/10/23. https://doi.org/10.1007/978-981-99-7243-2_36

Control of electrical and calcium alternans in a one-dimensional cardiac cable. / Keong, Jin; Lan, Boon Leong; Lim, Einly et al.
22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II. ed. / Fazilah Hassan; Noorhazirah Sunar; Mohd Ariffanan Mohd Basri; Mohd Saiful Azimi Mahmud; Mohamad Hafis Izran Ishak; Mohamed Sultan Mohamed Ali. 1st. ed. Singapore Singapore: Springer, 2024. p. 441-451 (Communications in Computer and Information Science; Vol. 1912).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AB - Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and thus, affect the effectiveness of controlling alternans. In this study, the control of cardiac alternans in a one-dimensional short cable was investigated numerically using the T± ϵ feedback control, where T is the basic cycle length and ϵ is a pre-set control parameter. The effectiveness of controlling alternans between action potential duration (APD) and peak value of intracellular calcium concentration (peak-[Ca]) being used as the feedback control variables were compared. Results showed that the effectiveness of APD-based and Ca-based feedback controls were the same when ϵ was less than the critical value (ϵc ), however, the APD-based control performed better than the Ca-based feedback control when ϵ> ϵc. This study may improve the understanding of which method is a better feedback control and lead to the development of a better alternans control scheme.

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Keong J, Lan BL, Lim E, Le DM, Liang SN. Control of electrical and calcium alternans in a one-dimensional cardiac cable. In Hassan F, Sunar N, Mohd Basri MA, Mahmud MSA, Ishak MHI, Mohamed Ali MS, editors, 22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II. 1st ed. Singapore Singapore: Springer. 2024. p. 441-451. (Communications in Computer and Information Science). doi: 10.1007/978-981-99-7243-2_36