Control of electrical and calcium alternans in a one-dimensional cardiac cable

Jin Keong, Boon Leong Lan, Einly Lim, Duy Manh Le, Shiuan Ni Liang

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review


Cardiac alternans is a beat-to-beat alternation in the electrical properties of the heart, such as membrane potential and intracellular calcium (Ca) cycling in myocytes. Due to the bi-directional coupling between voltage and calcium, it is not easy to decide which mechanism drives the alternans and thus, affect the effectiveness of controlling alternans. In this study, the control of cardiac alternans in a one-dimensional short cable was investigated numerically using the T± ϵ feedback control, where T is the basic cycle length and ϵ is a pre-set control parameter. The effectiveness of controlling alternans between action potential duration (APD) and peak value of intracellular calcium concentration (peak-[Ca]) being used as the feedback control variables were compared. Results showed that the effectiveness of APD-based and Ca-based feedback controls were the same when ϵ was less than the critical value (ϵc ), however, the APD-based control performed better than the Ca-based feedback control when ϵ> ϵc. This study may improve the understanding of which method is a better feedback control and lead to the development of a better alternans control scheme.

Original languageEnglish
Title of host publication22nd Asia Simulation Conference, AsiaSim 2023 Langkawi, Malaysia, October 25–26, 2023 Proceedings, Part II
EditorsFazilah Hassan, Noorhazirah Sunar, Mohd Ariffanan Mohd Basri, Mohd Saiful Azimi Mahmud, Mohamad Hafis Izran Ishak, Mohamed Sultan Mohamed Ali
Place of PublicationSingapore Singapore
Number of pages11
ISBN (Electronic)9789819972432
ISBN (Print)9789819972425
Publication statusPublished - 2024
EventAsia Simulation Conference 2023 - Langkawi, Malaysia
Duration: 25 Oct 202326 Oct 2023
Conference number: 22nd (Proceedings) (Website)

Publication series

NameCommunications in Computer and Information Science
ISSN (Print)1865-0929
ISSN (Electronic)1865-0937


ConferenceAsia Simulation Conference 2023
Abbreviated titleAsiaSim 2023
Internet address


  • Nonlinear dynamics and chaos
  • Cardiac dynamics
  • Feedback control
  • Applications of chaos

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