Control of mammalian kidney development by the Hedgehog signaling pathway

Jason Cain, Norman Rosenblum

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)


The kidney is the most common site of congenital malformations that result in impaired renal function. Yet, the molecular mechanisms that control renal malformations are poorly understood. The Hedgehog signaling pathway plays critical roles during mammalian organogenesis. Aberrant Hedgehog signaling results in severe congenital abnormalities, including renal malformations. Here, we review the current body of knowledge on Hedgehog signaling during renal morphogenesis and highlight the gaps in our understanding. Furthermore, we propose mechanisms by which Hedgehog signaling contributes to both normal and abnormal renal development.
Original languageEnglish
Pages (from-to)1365 - 1371
Number of pages7
JournalPediatric Nephrology
Issue number9
Publication statusPublished - 2011
Externally publishedYes

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