Control of granzymes by serpins

Dion Kaiserman, Phillip Ian Bird

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Abstract

Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the cytoprotective function that serpins have in safeguarding lymphocytes from granzymes that may leak from granules. We also discuss some of the pitfalls inherent in using rodent models of granzyme-serpin interactions and the ways in which our understanding of serpins can help resolve some of the current, contentious issues in granzyme biology.
Original languageEnglish
Pages (from-to)586 - 595
Number of pages9
JournalCell Death and Differentiation
Volume17
DOIs
Publication statusPublished - 2010

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