Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis

Tuhina Neogi, Anushka Soni, Sally A Doherty, Laura Louise Laslett, Rose A Maciewicz, Deborah J Hart, Weiya Zhang, Kenneth R Muir, Margaret Wheeler, Cyrus Cooper, Timothy D Spector, Flavia Maria Cicuttini, Graeme Jones, Michael C Nevitt, Y Liu, Nigel K Arden, Michael Doherty, Ana Maria Valdes

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13 Citations (Scopus)


We assessed whether the Met allele in the COMT gene is involved in increased risk of symptomatic knee OA in seven cohorts: five cohorts from the UK, one from Australia and two from the USA were included (table 1). Assembly of the cohorts was approved by the local research ethics committees and all study participants gave fully informed consent to participate in genetic studies.
Original languageEnglish
Pages (from-to)315 - 317
Number of pages3
JournalAnnals of the Rheumatic Diseases
Issue number1
Publication statusPublished - 2014

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