Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?

Mark A. Febbraio; Bente K. Pedersen

doi:10.1097/00003677-200507000-00003

Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?

Mark A. Febbraio, Bente K. Pedersen

Research output: Contribution to journal › Review Article › Research › peer-review

324 Citations (Scopus)

Abstract

The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

Original language	English
Pages (from-to)	114-119
Number of pages	6
Journal	Exercise and Sport Sciences Reviews
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/00003677-200507000-00003
Publication status	Published - 1 Jul 2005
Externally published	Yes

Keywords

Cytokines
Hepatic glucose production
Interleukin-6
Lipolysis
Metabolic processes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00003677-200507000-00003

Cite this

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title = "Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?",

abstract = "The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified {"}myokine{"} released from muscle that can now be termed an endocrine organ.",

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T2 - Is skeletal muscle an endocrine organ?

AU - Febbraio, Mark A.

AU - Pedersen, Bente K.

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Y1 - 2005/7/1

N2 - The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

AB - The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

KW - Cytokines

KW - Hepatic glucose production

KW - Interleukin-6

KW - Lipolysis

KW - Metabolic processes

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U2 - 10.1097/00003677-200507000-00003

DO - 10.1097/00003677-200507000-00003

M3 - Review Article

C2 - 16006818

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SN - 0091-6331

VL - 33

SP - 114

EP - 119

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 3

ER -

Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?

Abstract

Keywords

UN SDGs

Access to Document

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