Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?

Mark A. Febbraio, Bente K. Pedersen

Research output: Contribution to journalReview ArticleResearchpeer-review

306 Citations (Scopus)


The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
JournalExercise and Sport Sciences Reviews
Issue number3
Publication statusPublished - 1 Jul 2005
Externally publishedYes


  • Cytokines
  • Hepatic glucose production
  • Interleukin-6
  • Lipolysis
  • Metabolic processes

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