Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?

Mark A. Febbraio; Bente K. Pedersen

doi:10.1097/00003677-200507000-00003

Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?

Mark A. Febbraio, Bente K. Pedersen

Research output: Contribution to journal › Review Article › Research › peer-review

251 Citations (Scopus)

Abstract

The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

Original language	English
Pages (from-to)	114-119
Number of pages	6
Journal	Exercise and Sport Sciences Reviews
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/00003677-200507000-00003
Publication status	Published - 1 Jul 2005
Externally published	Yes

Keywords

Cytokines
Hepatic glucose production
Interleukin-6
Lipolysis
Metabolic processes

Access to Document

10.1097/00003677-200507000-00003

Link to publication in Scopus

Cite this

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title = "Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?",

abstract = "The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified {"}myokine{"} released from muscle that can now be termed an endocrine organ.",

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N2 - The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

AB - The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

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KW - Hepatic glucose production

KW - Interleukin-6

KW - Lipolysis

KW - Metabolic processes

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