Contraceptive Efficacy of a Depot Progestin and Androgen Combination in Men

Leo Turner, Ann J. Conway, Mark Jimenez, Peter Y. Liu, Elise Forbes, Robert I. McLachlan, David J. Handelsman

    Research output: Contribution to journalArticleResearchpeer-review

    133 Citations (Scopus)

    Abstract

    WHO studies provided proof of concept for hormonal male contraception using a prototype androgen-alone regimen. Combined testosterone plus progestin regimens offer more practical promise, but no contraceptive efficacy studies have been completed. The objective of this study was to establish the proof of principle for depot hormonal androgen/progestin combination as a male contraceptive. We performed a contraceptive efficacy study of 55 healthy men in stable fertile relationships seeking a change in contraceptive method. Testosterone (four 200-mg implants, every 4 or 6 months) and 300 mg depot medroxyprogesterone acetate, im, every 3 months were administered. Once sperm output was suppressed (

    Original languageEnglish
    Pages (from-to)4659-4667
    Number of pages9
    JournalThe Journal of Clinical Endocrinology and Metabolism
    Volume88
    Issue number10
    DOIs
    Publication statusPublished - Oct 2003

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