TY - JOUR
T1 - Contraceptive Efficacy of a Depot Progestin and Androgen Combination in Men
AU - Turner, Leo
AU - Conway, Ann J.
AU - Jimenez, Mark
AU - Liu, Peter Y.
AU - Forbes, Elise
AU - McLachlan, Robert I.
AU - Handelsman, David J.
PY - 2003/10
Y1 - 2003/10
N2 - WHO studies provided proof of concept for hormonal male contraception using a prototype androgen-alone regimen. Combined testosterone plus progestin regimens offer more practical promise, but no contraceptive efficacy studies have been completed. The objective of this study was to establish the proof of principle for depot hormonal androgen/progestin combination as a male contraceptive. We performed a contraceptive efficacy study of 55 healthy men in stable fertile relationships seeking a change in contraceptive method. Testosterone (four 200-mg implants, every 4 or 6 months) and 300 mg depot medroxyprogesterone acetate, im, every 3 months were administered. Once sperm output was suppressed (
AB - WHO studies provided proof of concept for hormonal male contraception using a prototype androgen-alone regimen. Combined testosterone plus progestin regimens offer more practical promise, but no contraceptive efficacy studies have been completed. The objective of this study was to establish the proof of principle for depot hormonal androgen/progestin combination as a male contraceptive. We performed a contraceptive efficacy study of 55 healthy men in stable fertile relationships seeking a change in contraceptive method. Testosterone (four 200-mg implants, every 4 or 6 months) and 300 mg depot medroxyprogesterone acetate, im, every 3 months were administered. Once sperm output was suppressed (
UR - http://www.scopus.com/inward/record.url?scp=0242383404&partnerID=8YFLogxK
U2 - 10.1210/jc.2003-030107
DO - 10.1210/jc.2003-030107
M3 - Article
C2 - 14557437
AN - SCOPUS:0242383404
SN - 0021-972X
VL - 88
SP - 4659
EP - 4667
JO - The Journal of Clinical Endocrinology & Metabolism
JF - The Journal of Clinical Endocrinology & Metabolism
IS - 10
ER -
