Continuous-infusion penicillin home-based therapy for serious infections due to penicillin-susceptible pathogens

Aaron L Walton, Benjamin Peter Howden, Lindsay M Grayson, Tony Korman

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To evaluate the feasibility of continuous-infusion (CI) penicillin in the treatment of serious bacterial infections, consecutive adult patients with deep-seated infections due to penicillin-susceptible pathogens were treated with CI aqueous penicillin G in a home-based programme, and their treatment outcomes were reviewed. Thirty-one patients with microbiologically proven infections completed the planned course of treatment. Twenty of 31 (65 ) were followed for at least 2 months thereafter, and all remained free of relapse. One patient had fever attributable to penicillin hypersensitivity, two patients developed catheter-site infections and one patient developed catheter-related bacteraemia. Thus, CI penicillin is feasible for the home-based treatment of a variety of deep-seated infections with minimal toxicity.
Original languageEnglish
Pages (from-to)544 - 548
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Issue number5
Publication statusPublished - 2007

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