Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

Melanie Kitchin, Kristina Konstas, Christopher J. Sumby, Milena L. Czyz, Peter Valente, Matthew R. Hill, Anastasios Polyzos, Christian J. Doonan

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20 Citations (Scopus)

Abstract

The facile synthesis of the cage molecule (C110H56Br2) via a remarkable three-fold homo-coupling macrocyclization reaction using continuous flow methodology is reported. Synthesis via continuous flow chemistry improves the residence time, safety, and environmental profile of this synthetically challenging reaction. Further, the new cage possesses halogen atoms at its apex that serve to expand the potential reaction space of these intrinsically porous, all carbon?carbon bonded molecular cage molecules.
Original languageEnglish
Pages (from-to)14231-14234
Number of pages4
JournalChemical Communications
Volume51
Issue number75
DOIs
Publication statusPublished - 28 Sep 2015
Externally publishedYes

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