Construction of phenoxazine rings containing nitro and sulfonic acid groups leading to phenoxazine-3-sulfonamide derivatives: their evaluation as novel and potential insulin secretagogues

Seelam Venkata Reddy, Gangula Mohan Rao, Baru Vijaya Kumar, Koppela Naresh Reddy, Konda Sravya, Puchchakayala Goverdhan, Vandana Rathore, Girdhar Singh Deora, Manojit Pal

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


A series of N-(alkyl/aryl/heteroaryl)-1-nitro-10H-phenoxazine-3- sulfonamides was designed, synthesized and evaluated for its hypoglycemic, hyperglycemic and oral anti-diabetic activities. These compounds were prepared via the construction of a phenoxazine ring containing nitro and sulfonic acid groups in a single step followed by further transformations. One of these compounds exhibited promising anti-diabetic activities comparable to glibenclamide and increased serum insulin levels indicating its potential as a novel insulin secretagogue. 

Original languageEnglish
Pages (from-to)587-592
Number of pages6
Issue number5
Publication statusPublished - 2014
Externally publishedYes

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