Consortium biology in immunology: the perspective from the Immunological Genome Project

Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis, Immunological Genome Project

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.
Original languageEnglish
Pages (from-to)734-740
Number of pages8
JournalNature Reviews Immunology
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 2012

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