Conservation of a unique mechanism of immune evasion across the Lyssavirus genus

Linda Wiltzer, F Larrous, Sibil Oksayan, Naoto Ito, Glenn A Marsh, Danielle Blondel, H Bourhy, David A Jans, Gregory W Moseley

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
Original languageEnglish
Pages (from-to)10194 - 10199
Number of pages6
JournalJournal of Virology
Volume86
Issue number18
DOIs
Publication statusPublished - 2012

Cite this

Wiltzer, L., Larrous, F., Oksayan, S., Ito, N., Marsh, G. A., Blondel, D., ... Moseley, G. W. (2012). Conservation of a unique mechanism of immune evasion across the Lyssavirus genus. Journal of Virology, 86(18), 10194 - 10199. https://doi.org/10.1128/JVI.01249-12
Wiltzer, Linda ; Larrous, F ; Oksayan, Sibil ; Ito, Naoto ; Marsh, Glenn A ; Blondel, Danielle ; Bourhy, H ; Jans, David A ; Moseley, Gregory W. / Conservation of a unique mechanism of immune evasion across the Lyssavirus genus. In: Journal of Virology. 2012 ; Vol. 86, No. 18. pp. 10194 - 10199.
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Wiltzer, L, Larrous, F, Oksayan, S, Ito, N, Marsh, GA, Blondel, D, Bourhy, H, Jans, DA & Moseley, GW 2012, 'Conservation of a unique mechanism of immune evasion across the Lyssavirus genus' Journal of Virology, vol. 86, no. 18, pp. 10194 - 10199. https://doi.org/10.1128/JVI.01249-12

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus. / Wiltzer, Linda; Larrous, F; Oksayan, Sibil; Ito, Naoto; Marsh, Glenn A; Blondel, Danielle; Bourhy, H; Jans, David A; Moseley, Gregory W.

In: Journal of Virology, Vol. 86, No. 18, 2012, p. 10194 - 10199.

Research output: Contribution to journalArticleResearchpeer-review

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AB - The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.

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Wiltzer L, Larrous F, Oksayan S, Ito N, Marsh GA, Blondel D et al. Conservation of a unique mechanism of immune evasion across the Lyssavirus genus. Journal of Virology. 2012;86(18):10194 - 10199. https://doi.org/10.1128/JVI.01249-12