Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 10194 - 10199 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 86 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2012 |
Cite this
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Conservation of a unique mechanism of immune evasion across the Lyssavirus genus. / Wiltzer, Linda; Larrous, F; Oksayan, Sibil; Ito, Naoto; Marsh, Glenn A; Blondel, Danielle; Bourhy, H; Jans, David A; Moseley, Gregory W.
In: Journal of Virology, Vol. 86, No. 18, 2012, p. 10194 - 10199.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Conservation of a unique mechanism of immune evasion across the Lyssavirus genus
AU - Wiltzer, Linda
AU - Larrous, F
AU - Oksayan, Sibil
AU - Ito, Naoto
AU - Marsh, Glenn A
AU - Blondel, Danielle
AU - Bourhy, H
AU - Jans, David A
AU - Moseley, Gregory W
PY - 2012
Y1 - 2012
N2 - The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
AB - The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
UR - http://jvi.asm.org/content/86/18/10194.full.pdf
U2 - 10.1128/JVI.01249-12
DO - 10.1128/JVI.01249-12
M3 - Article
VL - 86
SP - 10194
EP - 10199
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 18
ER -