TY - JOUR
T1 - Consequences of donor-derived passengers (pathogens, cells, biological molecules and proteins) on clinical outcomes
AU - Snell, Gregory
AU - Hiho, Steven
AU - Levvey, Bronwyn
AU - Sullivan, Lucy
AU - Westall, Glen
PY - 2019/9/1
Y1 - 2019/9/1
N2 - It is recognized that donor factors contribute to lung transplant outcomes. Recent observations and studies have started to elucidate potential mechanisms behind explaining these observations. This perspective piece summarizes evolving lung transplant literature on the subject, focusing on donor “passenger” organisms, cells, hormones, and proteins transferred to the recipient. Many extrinsic and intrinsic donor features or properties have important consequences for subsequent allograft function in the recipient. Potentially, a better understanding of these features may provide useful novel therapeutic targets to enhance allograft outcomes.
AB - It is recognized that donor factors contribute to lung transplant outcomes. Recent observations and studies have started to elucidate potential mechanisms behind explaining these observations. This perspective piece summarizes evolving lung transplant literature on the subject, focusing on donor “passenger” organisms, cells, hormones, and proteins transferred to the recipient. Many extrinsic and intrinsic donor features or properties have important consequences for subsequent allograft function in the recipient. Potentially, a better understanding of these features may provide useful novel therapeutic targets to enhance allograft outcomes.
KW - ex-vivo lung perfusion
KW - immunology
KW - lung transplantation
KW - microbiome
KW - passenger lymphocyte syndrome
UR - http://www.scopus.com/inward/record.url?scp=85068746568&partnerID=8YFLogxK
U2 - 10.1016/j.healun.2019.06.019
DO - 10.1016/j.healun.2019.06.019
M3 - Editorial
C2 - 31307786
AN - SCOPUS:85068746568
SN - 1053-2498
VL - 38
SP - 902
EP - 906
JO - The Journal of Heart and Lung Transplantation
JF - The Journal of Heart and Lung Transplantation
IS - 9
ER -