Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014

Christopher C. Blyth, N. M. Gilroy, S. D. Guy, Stephen T Chambers, E. Y. Cheong, Thomas Gottlieb, S. L. Mcguinness, Karin A Thursky

Research output: Contribution to journalReview ArticleOtherpeer-review

48 Citations (Scopus)

Abstract

Mould species represent the pathogens most commonly associated with invasive fungal disease in patients with haematological malignancies and patients of haemopoietic stem cell transplants. Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While Aspergillus species remain the most prevalent cause of invasive mould infections, Scedosporium and Fusarium species and the Mucormycetes continue to place a significant burden on the immunocompromised host. Evidence also suggests that infections caused by rare and emerging pathogens are increasing within the setting of broad-spectrum antifungal prophylaxis and improved survival times placing immunosuppressed patients at risk for longer. These guidelines present evidence-based recommendations for the antifungal management of common, rare and emerging mould infections in both adult and paediatric populations. Where relevant, the role of surgery, adjunctive therapy and immunotherapy is also discussed.

Original languageEnglish
Pages (from-to)1333-1349
Number of pages17
JournalInternal Medicine Journal
Volume44
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Keywords

  • Antifungal therapy
  • Aspergillosis
  • Emerging fungal infection
  • Invasive mould disease
  • Mucormycosis

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