Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014

Shaun Alan Fleming, Costas Yannakou, Gabrielle M Haeusler, Julia E Clark, Andrew P Grigg, Christopher H Heath, Ashish Bajel, Sebastiaan J M van Hal, S C Chen, Sam T Milliken, Orla Morrissey, Constantine Tam, Jeffrey Szer, Robert Weinkove, Monica Anne Slavin

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66 Citations (Scopus)


There is a strong argument for the use of antifungal prophylaxis in high-risk patients given the significant mortality associated with invasive fungal disease, the late identification of these infections, and the availability of safe and well-tolerated prophylactic medications. Clinical decisions about which patients should receive prophylaxis and choice of antifungal agent should be guided by risk stratification, knowledge of local fungal epidemiology, the efficacy and tolerability profile of available agents, and estimates such as number needed to treat and number needed to harm. There have been substantial changes in practice since the 2008 guidelines were published. These include the availability of new medications and/or formulations, and a focus on refining and simplifying patient risk stratification. Used in context, these guidelines aim to assist clinicians in providing optimal preventive care to this vulnerable patient demographic.
Original languageEnglish
Pages (from-to)1283 - 1297
Number of pages15
JournalInternal Medicine Journal
Issue number12b
Publication statusPublished - 2014

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