Conotoxins down under

Raymond S. Norton, Baldomero M. Olivera

Research output: Contribution to journalArticleResearchpeer-review

128 Citations (Scopus)

Abstract

In the four decades since toxinologists in Australia and elsewhere started to investigate the active constituents of venomous cone snails, a wealth of information has emerged on the various classes of peptides and proteins that make their venoms such potent bioactive cocktails. This article provides an overview of the current state of knowledge of these venom constituents, several of which are of interest as potential human therapeutics as a consequence of their high potency and exquisite target specificity. With the promise of as many as 50,000 venom components across the entire Conus genus, many more interesting peptides can be anticipated.

Original languageEnglish
Pages (from-to)780-798
Number of pages19
JournalToxicon
Volume48
Issue number7
DOIs
Publication statusPublished - 1 Dec 2006
Externally publishedYes

Keywords

  • Acetylcholine receptor
  • Cone snail
  • Ion channel
  • Peptide
  • Structure

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