Connectomic intermediate phenotypes for psychiatric disorders

Alex Fornito, Edward T Bullmore

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Abstract

Psychiatric disorders are phenotypically heterogeneous entities with a complex genetic basis. To mitigate this complexity, many investigators study so-called intermediate phenotypes (IPs) that putatively provide a more direct index of the physiological effects of candidate genetic risk variants than overt psychiatric syndromes. Magnetic resonance imaging (MRI) is a particularly popular technique for measuring such phenotypes because it allows interrogation of diverse aspects of brain structure and function in vivo. Much of this work however, has focused on relatively simple measures that quantify variations in the physiology or tissue integrity of specific brain regions in isolation, contradicting an emerging consensus that most major psychiatric disorders do not arise from isolated dysfunction in one or a few brain regions, but rather from disturbed interactions within and between distributed neural circuits; i.e., they are disorders of brain connectivity.
Original languageEnglish
Article number32
Number of pages15
JournalFrontiers in Psychiatry
Volume3
DOIs
Publication statusPublished - 19 Apr 2012
Externally publishedYes

Keywords

  • endophenotype
  • schizophrenia
  • depression
  • alzheimer's disease
  • anxiety
  • complex
  • graph analysis
  • default mode

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