Conjugate addition of nitrogen nucleophiles to an α,β-unsaturated pyrrolidinone

Philip W.H. Chan, Ian F. Cottrell, Mark G. Moloney

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34 Citations (Scopus)


The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield.

Original languageEnglish
Pages (from-to)5891-5894
Number of pages4
JournalTetrahedron Letters
Issue number33
Publication statusPublished - 18 Aug 1997
Externally publishedYes

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