Conjugate addition of nitrogen nucleophiles to an α,β-unsaturated pyrrolidinone

Philip W.H. Chan, Ian F. Cottrell, Mark G. Moloney

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Abstract

The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity. Deprotection provides a simple access to β-aminopyrrolidinones in excellent overall yield.

Original languageEnglish
Pages (from-to)5891-5894
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number33
DOIs
Publication statusPublished - 18 Aug 1997
Externally publishedYes

Cite this