Congenital malformations associated with a single umbilical artery in twin pregnancies

Sarah E. Mitchell, Karen Reidy, Fabricio Da Silva Costa, Ricardo Palma-Dias, Thomas J. Cade, Mark P. Umstad

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)


A single umbilical artery (SUA) was identified in 1.5% of twin pregnancies. The presence of a SUA in a twin pregnancy was associated with a 50% incidence of fetal anomalies, many of them complex and severe. The embryology and pathophysiological mechanisms associated with a SUA are reviewed. Aneuploidy is relatively common and should be considered, particularly in the presence of associated anomalies. Fetal growth restriction is frequent and preterm delivery is common.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalTwin Research and Human Genetics
Issue number5
Publication statusPublished - Oct 2015
Externally publishedYes


  • fetal anomalies
  • growth restriction
  • single umbilical artery
  • twins

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