Condom use in prevention of human papillomavirus infections and cervical neoplasia

Systematic review of longitudinal studies

Janni Uyen Hoa Lam, Matejka Rebolj, Pierre Antoine Dugué, Jesper Bonde, My von Euler-Chelpin, Elsebeth Lynge

Research output: Contribution to journalReview ArticleResearchpeer-review

39 Citations (Scopus)

Abstract

Objectives: Based on cross-sectional studies, the data on protection from Human Papillomavirus (HPV) infections related to using male condoms appear inconsistent. Longitudinal studies are more informative for this purpose. We undertook a systematic review of longitudinal studies on the effectiveness of male condoms in preventing HPV infection and cervical neoplasia. Methods: We searched PubMed using MeSH terms for articles published until May 2013. Articles were included if they studied a change in non-immunocompromized women's cervical HPV infection or cervical lesion status along with the frequency of condom use. Results: In total, 384 abstracts were retrieved. Eight studies reported in 10 articles met the inclusion criteria for the final review. Four studies showed a statistically significantly protective effect of consistent condom use on HPV infection and on regression of cervical neoplasia. In the remaining four studies, a protective effect was also observed for these outcomes, although it was not statistically significant. Conclusions: Consistent condom use appears to offer a relatively good protection from HPV infections and associated cervical neoplasia. Advice to use condoms might be used as an additional instrument to prevent unnecessary colposcopies and neoplasia treatments in cervical screening, and to reduce the risk of cervical cancer.

Original languageEnglish
Pages (from-to)38-50
Number of pages13
JournalJournal of Medical Screening
Volume21
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Cervical cancer
  • Cervical neoplasia
  • Condom
  • Human papillomavirus
  • Infection
  • Prevention

Cite this

Lam, Janni Uyen Hoa ; Rebolj, Matejka ; Dugué, Pierre Antoine ; Bonde, Jesper ; von Euler-Chelpin, My ; Lynge, Elsebeth. / Condom use in prevention of human papillomavirus infections and cervical neoplasia : Systematic review of longitudinal studies. In: Journal of Medical Screening. 2014 ; Vol. 21, No. 1. pp. 38-50.
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Condom use in prevention of human papillomavirus infections and cervical neoplasia : Systematic review of longitudinal studies. / Lam, Janni Uyen Hoa; Rebolj, Matejka; Dugué, Pierre Antoine; Bonde, Jesper; von Euler-Chelpin, My; Lynge, Elsebeth.

In: Journal of Medical Screening, Vol. 21, No. 1, 01.01.2014, p. 38-50.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Lam, Janni Uyen Hoa

AU - Rebolj, Matejka

AU - Dugué, Pierre Antoine

AU - Bonde, Jesper

AU - von Euler-Chelpin, My

AU - Lynge, Elsebeth

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N2 - Objectives: Based on cross-sectional studies, the data on protection from Human Papillomavirus (HPV) infections related to using male condoms appear inconsistent. Longitudinal studies are more informative for this purpose. We undertook a systematic review of longitudinal studies on the effectiveness of male condoms in preventing HPV infection and cervical neoplasia. Methods: We searched PubMed using MeSH terms for articles published until May 2013. Articles were included if they studied a change in non-immunocompromized women's cervical HPV infection or cervical lesion status along with the frequency of condom use. Results: In total, 384 abstracts were retrieved. Eight studies reported in 10 articles met the inclusion criteria for the final review. Four studies showed a statistically significantly protective effect of consistent condom use on HPV infection and on regression of cervical neoplasia. In the remaining four studies, a protective effect was also observed for these outcomes, although it was not statistically significant. Conclusions: Consistent condom use appears to offer a relatively good protection from HPV infections and associated cervical neoplasia. Advice to use condoms might be used as an additional instrument to prevent unnecessary colposcopies and neoplasia treatments in cervical screening, and to reduce the risk of cervical cancer.

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