Conclusion and future considerations of dendrimers

Sima Singh, Gunjan Singh, Shivani Sehrawat, Pinki Rawat, Nagashekhara Molugulu, Vijender Singh, Farhan J. Ahmed, Prashant Kesharwani

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

19 Citations (Scopus)

Abstract

Dendrimers are new hyperbranched globular and three-dimensional nanocarrier. Dendrimer nanocarriers are emergent as most attractive nanocarrier for gene and drug delivery vector. Availability of multiple surface functional groups allow conjugation of targeting moieties which can attract to receptors overexpressed on various cancer cells. It can be concluded that dendrimers show substantial potential as a versatile carrier for bioactives. However, the landing of dendrimer from seat of chemist to formulation desk is still far from complete. Interdisciplinary vision on dendrimer combination with other nanocarriers can be arise as a satisfying strategy. However, the toxicity of the constituents of nanohybrids, vis-a-vis the hybrid itself, will have to be discovered and recognized, if not ruled out.

Original languageEnglish
Title of host publicationDendrimer-Based Nanotherapeutics
EditorsPrasjant Kesharwani
Place of PublicationUnited Kingdom
PublisherElsevier
Chapter25
Pages449-458
Number of pages10
ISBN (Electronic)9780128212509
DOIs
Publication statusPublished - 2021

Keywords

  • Biocompatibility
  • Dendrimer
  • Drug delivery
  • Gene delivery
  • Nanoparticle
  • PAMAM
  • Surface engineering
  • Toxicity

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