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This chapter briefly reviews the progress that has been made in understanding the key chemical, microbiological and pharmacological properties of the polymyxins since they were resurrected for clinical use around the start of the current century. Discussed are some of the key outcomes of the first three international conferences on the poymyxins, including publication of a consensus statement on a framework for redevelopment of these last-line antibiotics and international consensus guidelines for their optimal use in patients.

Original languageEnglish
Title of host publicationPolymyxin Antibiotics
Subtitle of host publicationFrom Laboratory Bench to Bedside
EditorsJian Li, Roger L. Nation, Keith S. Kaye
Place of PublicationSwitzerland
Number of pages2
ISBN (Electronic)9783030163730
ISBN (Print)9783030163716
Publication statusPublished - 2019

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Colistin
  • Consensus statements and guidelines
  • Polymyxin B
  • Polymyxins
  • Progress in understanding how to use in patients

Cite this

Nation, R. L. (2019). Conclusion. In J. Li, R. L. Nation, & K. S. Kaye (Eds.), Polymyxin Antibiotics: From Laboratory Bench to Bedside (1st ed., pp. 363-364). (Advances in Experimental Medicine and Biology; Vol. 1145). Springer.