Abstract
Concise syntheses of two 3-polyenoyl-5-methylenefuran-2,4-diones, which are proposed to be key intermediates in the biosynthesis of the unusual 32-membered carbocycle-containing quartromicin antibiotics, are reported involving acylation of 3-lithio-4-methoxy-5-methylene-5H-furan-2-one as a key step.
| Original language | English |
|---|---|
| Pages (from-to) | 2164-2168 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 22 Aug 2008 |
| Externally published | Yes |
Keywords
- Acylations
- Antibiotics
- Biosynthesis
- Quartromicins
- Spirotetronates