Concise synthesis of key 3-polyenoyl-5-methylenefuran-2,4-dione putative intermediates in quartromicin biosynthesis

Laura J. Montgomery; Gregory L. Challis

doi:10.1055/s-2008-1078247

Concise synthesis of key 3-polyenoyl-5-methylenefuran-2,4-dione putative intermediates in quartromicin biosynthesis

Laura J. Montgomery, Gregory L. Challis

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Concise syntheses of two 3-polyenoyl-5-methylenefuran-2,4-diones, which are proposed to be key intermediates in the biosynthesis of the unusual 32-membered carbocycle-containing quartromicin antibiotics, are reported involving acylation of 3-lithio-4-methoxy-5-methylene-5H-furan-2-one as a key step.

Original language	English
Pages (from-to)	2164-2168
Number of pages	5
Journal	Synlett
Issue number	14
DOIs	https://doi.org/10.1055/s-2008-1078247
Publication status	Published - 22 Aug 2008
Externally published	Yes

Keywords

Acylations
Antibiotics
Biosynthesis
Quartromicins
Spirotetronates

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10.1055/s-2008-1078247

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AU - Challis, Gregory L.

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KW - Acylations

KW - Antibiotics

KW - Biosynthesis

KW - Quartromicins

KW - Spirotetronates

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JO - Synlett

JF - Synlett

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ER -

Concise synthesis of key 3-polyenoyl-5-methylenefuran-2,4-dione putative intermediates in quartromicin biosynthesis

Abstract

Keywords

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