Concise synthesis of key 3-polyenoyl-5-methylenefuran-2,4-dione putative intermediates in quartromicin biosynthesis

Laura J. Montgomery, Gregory L. Challis

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4 Citations (Scopus)

Abstract

Concise syntheses of two 3-polyenoyl-5-methylenefuran-2,4-diones, which are proposed to be key intermediates in the biosynthesis of the unusual 32-membered carbocycle-containing quartromicin antibiotics, are reported involving acylation of 3-lithio-4-methoxy-5-methylene-5H-furan-2-one as a key step.

Original languageEnglish
Pages (from-to)2164-2168
Number of pages5
JournalSynlett
Issue number14
DOIs
Publication statusPublished - 22 Aug 2008
Externally publishedYes

Keywords

  • Acylations
  • Antibiotics
  • Biosynthesis
  • Quartromicins
  • Spirotetronates

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