Concise review: Embryonic stem cells versus induced pluripotent stem cells: The game is on

Mira C. Puri, Andras Nagy

Research output: Contribution to journalReview ArticleResearchpeer-review

89 Citations (Scopus)

Abstract

Extraordinary advances in pluripotent stem cell research have initiated an era of hope for regenerative strategies to treat human disease. Besides embryonic stem cells, the discovery of induced pluripotent stem cells widened the possibility of patient-specific cell therapy, drug discovery, and disease modeling. Although similar, it has become clear that these two pluripotent cell types display significant differences. In this review, we explore current knowledge of the molecular and functional similarities and differences between these two cell types to emphasize the necessity for thorough characterization of their properties as well as their differentiation capabilities in the pluripotent state. Such comparative studies will be crucial for determining the more suitable cell type for future stem cell-based therapies for human degenerative diseases.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalStem Cells
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Keywords

  • Disease modeling
  • Embryonic stem cells
  • Genome integrity
  • Induced pluripotent stem cells
  • Pluripotency
  • Tumorigenicity

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