Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: A comparison with fractional flow reserve

Brian Ko, James Cameron, Ian Meredith, Michael Leung, Paul Antonis, Arthur Nasis, Marcus Crossett, Sarah Hope, Sam Lehman, John Troupis, Tony DeFrance, Sujith Seneviratne

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162 Citations (Scopus)


Aims Adenosine stress computed tomography myocardial perfusion imaging (CTP) is an emerging non-invasive method for detecting myocardial ischaemia. Its value when compared with fractional flow reserve (FFR), a highly accurate index of ischaemia, is unknown. Our aim was to determine the diagnostic accuracy of CTP and its incremental value when used with computed tomography coronary angiography (CTA) for detecting ischaemia compared with FFR. Methods and results Forty-two patients (126 vessel territories), who had at least one >/=50 angiographic stenosis on invasive angiography considered for non-urgent revascularization, were included and underwent FFR and CT assessment, including CTP, delayed contrast enhancement scan and CTA all acquired using 320-detector row CT, and prospective ECG gating. Fractional flow reserve was determined in 86 territories subtended by vessels with >/=50 stenosis upon visual assessment. Fractional flow reserve /=50 stenosis on CTA and perfusion defect on CTP was 98 specific for ischaemia, while the presence of
Original languageEnglish
Pages (from-to)67 - 77
Number of pages11
JournalEuropean Heart Journal
Issue number1
Publication statusPublished - 2012

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